Detalhe da pesquisa
1.
Magnetically powered microwheel thrombolysis of occlusive thrombi in zebrafish.
Proc Natl Acad Sci U S A
; 121(10): e2315083121, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38408253
2.
SORL1 is a receptor for tau that promotes tau seeding.
J Biol Chem
; : 107313, 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38657864
3.
Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCß phosphorylation of occludin.
Blood
; 140(4): 388-400, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35576527
4.
Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition.
J Biol Chem
; 298(12): 102608, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36257408
5.
Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin.
J Biol Chem
; 298(12): 102652, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36444882
6.
Opposing effects of ß-2 and ß-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity.
J Neuroinflammation
; 20(1): 56, 2023 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36864439
7.
Tissue Plasminogen Activator in Central Nervous System Physiology and Pathology: From Synaptic Plasticity to Alzheimer's Disease.
Semin Thromb Hemost
; 48(3): 288-300, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-34942669
8.
A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice.
Blood
; 135(19): 1704-1717, 2020 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32315384
9.
High-affinity binding of plasminogen-activator inhibitor 1 complexes to LDL receptor-related protein 1 requires lysines 80, 88, and 207.
J Biol Chem
; 295(1): 212-222, 2020 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31792055
10.
Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.
Arterioscler Thromb Vasc Biol
; 40(6): 1479-1490, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32268785
11.
Heparin and Arginine Based Plasmin Nanoformulation for Ischemic Stroke Therapy.
Int J Mol Sci
; 22(21)2021 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34768908
12.
Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate.
J Biol Chem
; 294(5): 1464-1477, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30510136
13.
Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose.
Am J Pathol
; 188(5): 1204-1212, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29454747
14.
A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.
Blood
; 127(9): 1085-96, 2016 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26647393
15.
tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS.
Semin Thromb Hemost
; 43(2): 154-168, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27677179
16.
Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.
Acta Neuropathol
; 134(4): 585-604, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28725968
17.
Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.
Acta Neuropathol
; 131(3): 453-64, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26687981
18.
Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVß3 integrin cross talk.
Arterioscler Thromb Vasc Biol
; 35(1): 111-20, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25378411
19.
Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.
Proc Natl Acad Sci U S A
; 110(51): E4941-9, 2013 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24297881
20.
Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts.
Lab Invest
; 94(6): 633-44, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24687120